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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
33.64
Human Site:
S529
Identified Species:
52.86
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
S529
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
S529
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
S529
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
Dog
Lupus familis
XP_538730
651
74149
S529
K
G
T
K
V
F
G
S
L
E
R
G
L
D
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
S521
K
G
T
N
V
F
G
S
L
E
R
G
L
D
K
Rat
Rattus norvegicus
P54645
559
63955
S453
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
S533
K
G
T
G
V
F
G
S
L
E
R
G
L
D
K
Chicken
Gallus gallus
NP_001026680
657
74208
S535
R
K
A
K
L
F
G
S
L
E
R
G
L
D
K
Frog
Xenopus laevis
NP_001081569
651
74289
S529
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
Q786
T
L
A
Q
T
L
P
Q
Q
Q
V
T
I
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
L500
S
D
D
P
K
Y
V
L
S
Q
L
R
R
A
L
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
S582
L
P
Q
R
V
F
T
S
L
E
R
K
K
E
K
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
F849
A
K
K
I
F
G
S
F
E
K
G
I
D
K
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
Q334
E
N
L
F
D
P
E
Q
E
F
K
R
E
T
R
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
E521
Y
P
L
D
V
M
G
E
I
Y
I
A
L
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
93.3
N.A.
86.6
6.6
N.A.
86.6
80
100
6.6
N.A.
N.A.
0
46.6
0
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
20
N.A.
86.6
93.3
100
26.6
N.A.
N.A.
13.3
60
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
40
0
0
0
0
0
0
0
0
7
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
7
7
0
0
0
0
0
0
0
7
54
0
% D
% Glu:
7
0
0
0
0
0
7
7
14
60
0
0
7
7
0
% E
% Phe:
0
0
0
7
7
60
0
7
0
14
0
0
0
0
0
% F
% Gly:
0
47
0
7
0
7
60
0
0
0
7
54
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
0
0
7
0
7
7
7
0
0
% I
% Lys:
47
14
14
40
7
0
0
0
0
7
7
14
7
14
60
% K
% Leu:
7
7
14
0
7
7
0
7
60
0
7
0
60
0
14
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
7
% M
% Asn:
0
7
0
14
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
0
14
0
7
7
7
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
7
7
0
0
0
14
7
14
0
0
0
7
0
% Q
% Arg:
14
7
0
7
0
0
0
0
0
0
60
14
7
0
7
% R
% Ser:
7
0
0
0
0
0
7
67
7
0
7
0
0
7
0
% S
% Thr:
7
0
20
0
7
0
14
0
7
0
0
7
0
7
0
% T
% Val:
0
0
0
0
60
7
7
0
0
0
7
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _